In a clinical study with adults with obese tendencies, a significantly lowered body fat mass was observed in the B-3 intake group who were orally administrated B-3 capsule in doses of 50 billion per day compared to the placebo group.

Examination by CT scan in a rat study showed a reduction in both subcutaneous and visceral fat.

High fat diet causes collapse of intestinal barrier function, which allows the invasion of inflammatory substances such as endotoxin lipopolysaccharide (LPS) to blood and leads to systemic inflammation in the body. B-3 plays a role in improving the intestinal barrier function, which results in repressed systemic inflammation reaction and controlled obesity.